{"id":8868,"date":"2023-06-06T16:27:38","date_gmt":"2023-06-06T08:27:38","guid":{"rendered":"https:\/\/newsletter.cgust.edu.tw\/?p=8868"},"modified":"2023-06-06T16:27:41","modified_gmt":"2023-06-06T08:27:41","slug":"%e4%b8%b9%e5%8f%83%e9%85%ae-iia-%e6%8a%91%e5%88%b6%e7%87%92%e9%a6%99%e5%be%ae%e7%b2%92%e8%aa%98%e7%99%bc%e6%98%9f%e5%bd%a2%e8%86%a0%e8%b3%aa%e7%b4%b0%e8%83%9e%e7%9a%84%e6%b0%a7%e5%8c%96%e5%a3%93","status":"publish","type":"post","link":"https:\/\/newsletter.cgust.edu.tw\/?p=8868","title":{"rendered":"\u4e39\u53c3\u916e IIA \u6291\u5236\u71d2\u9999\u5fae\u7c92\u8a98\u767c\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u7684\u6c27\u5316\u58d3\u529b\u548c\u767c\u708e\u8def\u5f91"},"content":{"rendered":"\n<p>2023\/05\/30\/\u6162\u6027\u75be\u75c5\u66a8\u5065\u5eb7\u4fc3\u9032\u7814\u7a76\u4e2d\u5fc3\/\u4f55\u96c5\u96ef<br><\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" 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class=\"has-medium-font-size\">\u5df2\u77e5\u61f8\u6d6e\u5fae\u7c92\u53ef\u4fc3\u9032\u6d3b\u6027\u6c27(reactive oxygen species, ROS)\u7522\u751f\uff0c\u53ef\u80fd\u7a7f\u904e\u8840\u8166\u5c4f\u969c\u5c0d\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71(central nervous system, CNS) \u7522\u751f\u4e0d\u826f\u5f71\u97ff\uff0c\u66f4\u53ef\u8a98\u767c\u591a\u7a2e\u75be\u75c5\uff0c\u5305\u62ec\u547c\u5438\u7cfb\u7d71\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u76ae\u819a\u75be\u75c5\uff0c\u751a\u81f3\u764c\u75c7\u3002 \u795e\u7d93\u81a0\u8cea\u7d30\u80de-\u661f\u5f62\u81a0\u8cea\u7d30\u80de \u661f\u72c0\u81a0\u7d30\u80de(astrocytes\u70ba\u795e\u7d93\u81a0\u8cea\u7d30\u80de\u7684\u4e00\u7a2e\uff0c\u5206\u4f48\u5ee3\u6cdb\u4e14\u6578\u91cf\u8c50\u5bcc\u662f\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u4e2d\u7684\u91cd\u8981\u7d44\u6210\uff0c\u4e3b\u8981\u8ca0\u8cac\u7dad\u6301\u3001\u7a69\u5b9a\u795e\u7d93\u7db2\u7d61\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size\">\u5728\u661f\u72c0\u81a0\u7d30\u80de\u6578\u91cf\u3001\u5927\u5c0f\u7522\u751f\u7570\u5e38\u6642\u5c07\u5c0e\u81f4\u795e\u7d93\u7d30\u80de\u6b7b\u4ea1\uff0c\u7814\u7a76\u5df2\u77e5\u91cd\u91d1\u5c6c\u7684\u66b4\u9732(\u5982\u7532\u57fa\u6c5e (MeHg))\u5c07\u6e1b\u5c11\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u7684\u6578\u91cf\uff0c\u800c\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u529f\u80fd\u969c\u7919\u53ef\u80fd\u5c0e\u81f4\u6c27\u5316\u58d3\u529b\u3001\u767c\u708e\u53cd\u61c9\u548c\u96a8\u5f8c\u7684\u795e\u7d93\u7d30\u80de\u9000\u5316\uff0c\u9019\u4e5f\u8207\u795e\u7d93\u9000\u884c\u6027\u75be\u75c5\u7684\u767c\u5c55\u6709\u95dc \u4e39\u53c3\u916e IIA\u7684\u4fdd\u8b77\u4f5c\u7528 \u4e39\u53c3(Salvia miltiorrhiza Bunge)\u662f\u6700\u65e9\u51fa\u73fe\u7684\u4e00\u7a2e\u4e2d\u85e5\uff0c\u4e39\u53c3\u6839\u53ef\u5206\u96e2\u51fa\u591a\u9054 40 \u7a2e\u4e39\u53c3\u916e\uff0c\u5176\u4e2d\u4e39\u53c3\u916e IIA 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\u672c\u7814\u7a76\u8a55\u4f30\u62dc\u9999\u7522\u751f\u4e4bPM2.5\u5fae\u7c92\u7684\u5316\u5b78\u7d44\u6210\uff0c\u4e26\u4ee5\u5927\u9f20\u52d5\u7269\u6a21\u5f0f\u63a2\u8a0e\u62dc\u9999PM2.5\u5fae\u7c92\u5c0d\u5927\u9f20\u661f\u5f62\u81a0\u8cea\u7d30\u80de (CTX-TNA2) \u662f\u5426\u5177\u6709\u751f\u7269\u6bd2\u6027\u4f5c\u7528\u3002\u540c\u6642\u63a2\u8a0e\u4e39\u53c3\u916e IIA\u7684\u4fdd\u8b77\u4f5c\u7528\u548c\u6f5b\u5728\u7684\u5206\u5b50\u6a5f\u5236\u3002\u62dc\u9999\u71c3\u71d2\u7522\u751fPM2.5\u5fae\u7c92\u7684\u7d44\u6210\u5206\u6790\u767c\u73fe\uff0c\u91cd\u91d1\u5c6c\u5e73\u5747\u6fc3\u5ea66458 \u03bcg\/g PM2.5\uff0c\u4ee5\u9240(K)\u3001\u9209(Na)\u4f54\u6bd4\u4f8b\u6700\u5927(98%)\uff0c\u5176\u6b21\u4f9d\u5e8f\u70ba\u92c1(Al)\u3001\u9382(Mg)\u3001\u92c5(Zn)\u3001\u9435(Fe)\u3001\u925b(Pb)\u7b49\u5fae\u91cf\u91d1\u5c6c\uff1bPAHs\u5e73\u5747\u6fc3\u5ea6154.19 \u00b1 23.30 \u03bcg\/g PM2.5\uff0c\u4e3b\u8981\u4ee5phenanthrene\u3001pyrene\u3001fluoranthene\u3001chrysene\u8207anthracene\u7d44\u6210\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size\">\u7d30\u80de\u6bd2\u6027\u7d50\u679c\u986f\u793a\u62dc\u9999\u7522\u751f\u4e4bPM2.5\u5fae\u7c92\u5c0d\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u5177\u6709\u751f\u7269\u6bd2\u6027\uff0c\u5c0e\u81f4\u65e9\u671f\u548c\u665a\u671f\u7d30\u80de\u51cb\u4ea1\u3001\u6d3b\u6027\u6c27(ROS) \u7522\u751f\u3001MAPK\uff08JNK\u3001p38\u3001ERK\uff09\u548cAkt\u4fe1\u865f\u6d3b\u5316\u548c\u708e\u75c7\u76f8\u95dc\u86cb\u767d\uff08cPLA2\u3001COX-2\u3001HO-1\u3001MMP-9\uff09\u589e\u52a0\u3002\u540c\u6642\u4e5f\u767c\u73fe\u4e39\u53c3\u916e IIA\u7684\u524d\u8655\u7406(pre-treatment)\u53ef\u4ee5\u986f\u8457\u907f\u514d\u71d2\u9999\u5fae\u7c92\u8a98\u767c\u7684\u5927\u9f20\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u51cb\u4ea1\u548c\u767c\u708e\u53cd\u61c9\u4fe1\u865f\u3002\u9019\u4e9b\u767c\u73fe\u986f\u793a\uff0c\u7528\u65bc\u9810\u9632\u8207\u71d2\u9999\u5fae\u7c92\u76f8\u95dc\u7684\u4e0d\u826f\u5065\u5eb7\u5f71\u97ff\u4e0a\uff0c\u4e39\u53c3\u916e IIA \u4f5c\u70ba\u5019\u9078\u85e5\u7269\u7684\u5177\u6709\u6f5b\u529b\u3002 <\/p>\n\n\n\n<p class=\"has-medium-font-size\">Chi, M. C., Lin, Z. C., Lee, C. W., Huang, C. C. Y., Peng, K. T., Lin, C. M., &#8230; &amp; Chiang, Y. C. (2023). Tanshinone IIA suppresses burning incense-induced oxidative stress and inflammatory pathways in astrocytes. Ecotoxicology and Environmental Safety, 258, 114987.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2023\/05\/30\/\u6162\u6027\u75be\u75c5\u66a8\u5065\u5eb7\u4fc3\u9032<\/p>\n","protected":false},"author":1,"featured_media":8869,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","_eb_attr":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-8868","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teaching"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>\u4e39\u53c3\u916e IIA \u6291\u5236\u71d2\u9999\u5fae\u7c92\u8a98\u767c\u661f\u5f62\u81a0\u8cea\u7d30\u80de\u7684\u6c27\u5316\u58d3\u529b\u548c\u767c\u708e\u8def\u5f91 - 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