{"id":870,"date":"2018-11-19T00:00:32","date_gmt":"2018-11-18T16:00:32","guid":{"rendered":"https:\/\/newsletter.cgust.edu.tw\/?p=870"},"modified":"2019-03-14T11:09:28","modified_gmt":"2019-03-14T03:09:28","slug":"%e3%80%90%e7%94%a2%e5%ad%b8%e5%90%88%e4%bd%9c%e6%88%90%e6%9e%9c%e5%88%86%e4%ba%ab%e3%80%91%e7%94%a2%e5%ad%b8%e5%90%88%e4%bd%9c%e6%8a%80%e8%a1%93%e7%a0%94%e7%99%bc%e7%b8%be%e5%84%aa%e7%8d%8e%e5%8b%b5","status":"publish","type":"post","link":"https:\/\/newsletter.cgust.edu.tw\/?p=870","title":{"rendered":"\u3010\u7522\u5b78\u5408\u4f5c\u6210\u679c\u5206\u4eab\u3011\u7522\u5b78\u5408\u4f5c\u6280\u8853\u7814\u767c\u7e3e\u512a\u734e\u52f5\u7372\u734e\u6559\u5e2b\u767c\u8868\u7814\u7a76\u52d5\u614b\u5831\u5c0e_\u8b77\u7406\u7cfb\u90ed\u661f\u541b\u6559\u6388"},"content":{"rendered":"\n<p><em>\u7531\u00a0<a href=\"http:\/\/120.126.208.48:8088\/Newsletter\/user\/429\">\u9673\u96c5\u745c<\/a>\u00a0\u5728 2018\/11\/19 &#8211; \u661f\u671f\u4e00 \u767c\u8868<\/em><\/p>\n\n\n\n<p class=\"has-medium-font-size\"> <br>\u9577\u5e9a\u79d1\u6280\u5927\u5b78\u5609\u7fa9\u5206\u90e8\u8b77\u7406\u7cfb\u57fa\u790e\u91ab\u5b78\u7d44\u90ed\u661f\u541b\u8001\u5e2b\uff0c\u4eca\u5e74\u7372\u9812\u672c\u6821\u5b78\u8853\u4f5c\u54c1\u767c\u8868\u7e3e\u512a\u734e\u7684\u7814\u7a76\u6559\u5e2b\uff0c\u4e5f\u7372\u672c\u5e74\u5ea6(107)\u7522\u5b78\u5408\u4f5c\u8a08\u756b\u6e1b\u6388\u6388\u8ab2\u6642\u6578\u734e\u52f5\u3002 <\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><img fetchpriority=\"high\" decoding=\"async\" width=\"366\" height=\"345\" src=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/00.png\" alt=\"\" class=\"wp-image-872\" srcset=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/00.png 366w, https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/00-300x283.png 300w\" sizes=\"(max-width: 366px) 100vw, 366px\" \/><\/figure><\/div>\n\n\n\n<p class=\"has-medium-font-size\">\u90ed\u8001\u5e2b\u5be6\u9a57\u5ba4\uff0c\u904b\u7528\u9ad8\u901a\u91cf\u86cb\u767d\u8cea\u8cea\u8b5c\u57fa\u790e\u751f\u7269\u6280\u8853\uff0c\u5927\u898f\u6a21\u5206\u6790\u9577\u5e9a\u81e8\u5e8a\u6a23\u672c(\u5927\u8178\u764c<sup>1<\/sup>\u3001\u809d\u81bd\u80c3<sup>2,3<\/sup>\u3001\u7259\u5468\u75c5<sup>4<\/sup>\u3001\u5152\u79d1\u5ddd\u5d0e\u6c0f\u75c7\uff08KD\uff09<sup>5<\/sup>&nbsp;)\uff0c\u4e26\u4e14\u7d93\u5206\u5b50\u751f\u7269\u7684\u57fa\u56e0\u8abf\u63a7\u5206\u6790\u5176\u751f\u7269\u6a19\u5e5f(biomarker)\u4e4b\u529f\u80fd\u6027\uff0c\u8b93\u4ee5\u5f80\u75be\u75c5\u7814\u7a76\u4e0a\u7684\u5206\u5b50\u81f4\u75c5\u6a5f\u8f49\u7684\u6210\u679c\uff0c\u53ef\u80fd\u904b\u7528\u65bc\u81e8\u5e8a\u6cbb\u7642\u3002\u90ed\u8001\u5e2b\u81ea2006\u5e74\u53d6\u5f97\u751f\u5316\u535a\u58eb\u5b78\u4f4d\u5f8c\uff0c2006-2008\uff0896\/3 ~ 97\/7\uff09\u6b77\u7d93\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u535a\u58eb\u5f8c\u7814\u7a76\u3001\u9ad8\u96c4\u9577\u5e9a\u91ab\u9662\u81e8\u5e8a\u57fa\u56e0\u9ad4\u66a8\u86cb\u767d\u8cea\u6838\u5fc3\u5be6\u9a57\u5ba4\u64d4\u4efb\u535a\u58eb\u7814\u7a76\u54e1\u3002\u90ed\u661f\u541b\u8001\u5e2b\u7814\u7a76\u5ba4\uff1a\u529f\u80fd\u6027\u86cb\u767d\u8cea\u9ad4\u7814\u7a76\u5ba4\u6210\u54e1\u67096\u4f4d\u5c08\u4efb\u78a9\u58eb\u7d1a\u7814\u7a76\u52a9\u7406\u82071\u4f4d\u78a9\u58eb\u751f\u3002\u958b\u767c\u5929\u7136\u7269\u8403\u53d6\u7269\uff0c\u63d0\u4f9b\u8f14\u52a9\u6cbb\u7642\u7684\u53ef\u80fd\uff0c\u5f97\u4ee5\u9023\u7d50\u8f49\u8b6f\u91ab\u5b78\uff1b\u76ee\u524d\u9032\u884c\u7814\u7a76\uff0c\u7576\u4e2d\u5c24\u4ee5\u81f4\u764c\u6a5f\u8f49\u6700\u80fd\u5f15\u8d77\u6700\u5927\u4e4b\u8208\u8da3\u3002\u5728\u81e8\u5e8a\u4e0a\u89c0\u5bdf\u5230\u816b\u7624\u7684\u8f49\u79fb\u53ca\u9810\u5f8c\u7684\u591a\u8b8a\u6027\uff0c\u56e0\u6b64\u5c0d\u65bc\u816b\u7624\u8f49\u79fb\u6a5f\u5236\u53ca\u5176\u8f14\u52a9\u6cbb\u7642\u6709\u76f8\u7576\u7684\u8208\u8da3\u3002\u800c\u90ed\u8001\u5e2b\u7684\u7522\u5b78\u8a08\u5283\u8207\u8461\u8404\u738b\u751f\u6280\u516c\u53f8\u958b\u767c\u5929\u7136\u8403\u53d6\u7269\u5c07\u63d0\u4f9b\u8f14\u52a9\u6cbb\u7642\u7684\u53ef\u80fd\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size\">&nbsp; &nbsp; \u7522\u5b78\u8a08\u5283\u4e43\u5354\u52a9\u958b\u767c\u7334\u982d\u83cc\u83cc\u7d72\u9ad4\u767c\u9175\u6280\u8853\uff1b\u5229\u7528 Hericium erinaceus \u83cc\u7d72\u9ad4\u767c\u9175\u7269\uff0c\u518d\u76ee\u524d\u7d93\u7531HPLC\u5b9a\u6027\u5b9a\u91cf\u5206\u6790\u6709\u6548\u6210\u5206\u7334\u982d\u7d20A\uff0c\u8207 NMR \u5206\u6790\u51fa\u7d50\u69cb\uff0c\u8a72\u767c\u9175\u88fd\u7a0b\u53ef\u4ee5\u5f97\u5230\u5728\u6bcf\u516c\u65a4\u7334\u982d\u83c7\u985e\u83cc\u7d72\u9ad4\u51cd\u4e7e (Hericium erinaceus wet mycelium)\uff0c\u6d3b\u6027\u6210\u5206\u7334\u982d\u7d20(Erinacine A\uff0c PubChem CID: 9867477)\u7d04 3-5 g6\uff0c\u5728\u6bcf\u516c\u65a4\u7334\u982d\u83c7\u83cc\u7d72\u9ad4\u51cd\u4e7e\u54c1(Hericium erinaceus wet mycelium)\u9032\u4e00\u6b65\u4eca\u5e74\u63d0\u7684\u8a08\u5283\u6848\u5728\u53bb\u5e74\u7684\u57fa\u790e\u4e0a\uff0c\u7d14\u5316\u539f\u5275\u7334\u982d\u83c7\u985e\u83cc\u7d72\u9ad4\u6d3b\u6027\u7522\u7269\u7334\u982d\u7d20 S (Erinacine S\uff0c PubChem CID: 127047879)\uff0c\u7334\u982d\u7d20 C (Erinacine C\uff0c PubChem CID: 15235994) \u9019\u88fd\u7a0b\u518d\u7d93\u7531 HPLC \u5b9a\u6027\u5b9a\u91cf\u5206\u6790\uff0c NMR \u5206\u6790\u51fa\u7d50\u69cb\uff0c\u53ef\u4ee5\u5f97\u5230\u6d3b\u6027\u6210\u5206\u7d04 2.0-3.0 g\uff1b\u6e96\u5099\u9032\u884c\u63a2\u8a0e\u5d84\u65b0\u5929\u7136\u7269\u7334\u982d\u7d20 S (Erinacine S)\u6291\u5236\u4eba\u985e\u80c3\u8178\u764c\u7d30\u80de\u8f49\u79fb\u4fb5\u8972\u8207\u8868\u89c0\u907a\u50b3\u8abf\u63a7\u6240\u626e\u6f14\u4e4b\u89d2\u8272\u7684\u76f8\u95dc\u6027\u6a5f\u5236\u7814\u7a76\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size\">&nbsp; &nbsp; \u76ee\u524d\u5e7e\u500b\u7814\u7a76\u55ae\u4f4d\u767c\u8868\u95dc\u65bc\u7334\u982d\u83c7\u5b50\u5be6\u9ad4\u8403\u53d6\u6210\u5206\u6297\u809d\u764c\u3001\u6297\u661f\u72c0\u7d30\u80de\u7624\u3001\u6297\u80c3\u764c\u3001\u6297\u8840\u764c\uff1b\u7136\u800c\u90ed\u8001\u5e2b\u91dd\u5c0d\u7334\u982d\u83c7\u83cc\u7d72\u9ad4\u9152\u7cbe\u8403\u53d6\u4e4b\u6d3b\u6027\u6210\u5206\u7334\u982d\u7d20\uff0c\u6297\u5927\u8178\u764c\u3001\u6297\u80c3\u764c\u6a5f\u5236\u4ecd\u4e0d\u751a\u6e05\u695a\u3002\u800c\u91dd\u5c0d\u958b\u767c\u7684\u7334\u982d\u83c7\u985e\u83cc\u7d72\u9ad4\u6d3b\u6027\u7522\u7269\uff0c\u9032\u884c\u6297\u764c\u4e4b\u529f\u80fd\u6027\u958b\u767c\uff0c\u9810\u9632\u6216\u6e1b\u5c11\u5927\u8178\u76f4\u8178\u764c\u3001\u80c3\u764c\u7684\u50b7\u5bb3\u7684\u7522\u54c1\uff0c\u53ef\u671b\u9032\u4e00\u6b65\u62d3\u5c55\u83c7\u985e\u4fdd\u5065\u7522\u54c1\u5347<sup>7,8,9<\/sup>\u3002\u6b64\u5916\uff0c\u90ed\u8001\u5e2b\u958b\u767c\u7334\u982d\u83cc\u83cc\u7d72\u9ad4\u4fdd\u8b77\u8166\u795e\u7d93\u7d30\u80de\u767c\u708e\u6240\u626e\u6f14\u7684\u89d2\u8272\u76f8\u95dc\u6027\uff0c\u5728\u7f3a\u8840\u518d\u704c\u6d41\u50b7\u5bb3\u640d\u50b7\u3001\u5df4\u91d1\u68ee\u6c0f\u75c7\u6cbb\u7642\u6a5f\u5236\u7684\u5065\u5eb7\u7522\u54c1\u63d0\u4f9b\u7406\u8ad6\u57fa\u790e<sup>10<\/sup>\u3002<\/p>\n\n\n\n<p>\u9644\u6ce8 1\uff1aHuang WS\u2020 , Hsieh MC\u2020 , Huang CY, Kuo YH, Tung SY, Shen CH, Hsieh YY, Teng CC, Lee KF, Chen TC, Lee KC, Kuo HC*. The Association of CXC Receptor 4 mediated signaling pathway with oxaliplatin-resistant human colorectal cancer cells. PLOS One. 11 (2016), e0159927.<\/p>\n\n\n\n<p>\u9644\u6ce8 2\uff1aHsieh YY, Shen CH, Huang WS, Chin CC, Kuo YH, Hsieh MC, Yu HR, Chang TS, Lin TH, Chiu YW, Chen CN, Kuo HC*, Tung SY. Resistin-induced stromal cell-derived factor-1 expression through Toll-like receptor 4 and activation of p38 MAPK\/ NFkappaB signaling pathway in gastric cancer cells. J Biomed Sci. 21 (2014), 59.<\/p>\n\n\n\n<p>\u9644\u6ce8 3\uff1aShen CH, Tung SY, Huang WS, Lu CC, Lee KC, Hsieh YY, Chang PJ, Liang HF, Chen JH, Lin TH, Hsieh MC, Kuo HC. Exploring the effects of tert-butylhydroperoxide induced liver injury using proteomic approach. Toxicology 316 (2014), 61-70.<\/p>\n\n\n\n<p>\u9644\u6ce8 4\uff1aKuo HC, Chang LC, Chen TC, Lee KC, Lee KF, Chen CN, Yu HR. Sterol Regulatory Element-Binding Protein-1c Regulates Inflammasome Activation in Gingival Fibroblasts Infected with High-Glucose-Treated Porphyromonas gingivalis. Front Cell Infect Microbiol. 6 (2016), 195.<\/p>\n\n\n\n<p>\u9644\u6ce8 5\uff1aKuo HC, Chang JC, Kuo HC, Yu HR, Wang CL, Lee CP, Huang LT, Yang KD. Identification of an Association Between Genomic Hypomethylation of FCGR2A and Susceptibility to Kawasaki Disease and Intravenous Immunoglobulin Resistance by DNA Methylation Array. Arthritis Rheumatol 67 (2015), 828-836.<\/p>\n\n\n\n<p>\u9644\u6ce8 6\uff1aLee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, Chen CC, Huang WS, Kuo HC*. Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS\/p38 MAPK and Nitrotyrosine. Int. J. Mol. Sci. 15 (2014), 15073-15089.<\/p>\n\n\n\n<p>\u9644\u6ce8 7\uff1aKuo HC, Kuo YR, Lee KF, Hsieh MC, Huang CY, Hsieh YY, Lee KC, Kuo HL, Lee LY, Chen WP, Chen CC, Tung SY. A Comparative Proteomic Analysis of Erinacine A&#8217;s Inhibition of Gastric Cancer Cell Viability and Invasiveness. Cell Physiol Biochem. 43 (2017), 195-208.<\/p>\n\n\n\n<p>\u9644\u6ce8 8\uff1a Lee KC, Kuo HC, Shen CH Lu CC, Huang WS, Hsieh MC, Huang CY, Kuo YH, Hsieh YY, Teng CC, Lee LY, Tung SY. A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells&#8217; aggressiveness. J Cell Mol Med. 21 (2017), 588-599.<\/p>\n\n\n\n<p>\u9644\u6ce8 9\uff1aLu CC, Huang WS, Lee KF, Lee KC, Hsieh MC, Huang CY, Lee LY, Lee BO, Teng CC, Shen CH, Tung SY, Kuo HC*. Inhibitory effect of Erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21. J Funct Foods. 21 (2016), 474-484.<\/p>\n\n\n\n<p>\u9644\u6ce8 10\uff1aKuo HC\u2020 , Lu CC, Shen CH, Tung SY, Hsieh MC, Lee KC, Lee LY, Chen CC, Teng CC, Huang WS, Chen TE, Lee KF. Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med. 14 (2016), 78.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"731\" height=\"479\" src=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/01_0.png\" alt=\"\" class=\"wp-image-873\" srcset=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/01_0.png 731w, https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/01_0-300x197.png 300w\" sizes=\"(max-width: 731px) 100vw, 731px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"695\" height=\"464\" src=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/02_0.png\" alt=\"\" class=\"wp-image-874\" srcset=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/02_0.png 695w, https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2019\/03\/02_0-300x200.png 300w\" sizes=\"(max-width: 695px) 100vw, 695px\" \/><\/figure>\n\n\n\n<p><br><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7531\u00a0\u9673\u96c5\u745c\u00a0\u5728 2018\/11\/19 &#038;<\/p>\n","protected":false},"author":1,"featured_media":872,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","_eb_attr":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-870","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teaching"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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