{"id":2309,"date":"2019-08-27T11:37:48","date_gmt":"2019-08-27T03:37:48","guid":{"rendered":"https:\/\/newsletter.cgust.edu.tw\/?p=2309"},"modified":"2019-09-16T17:16:10","modified_gmt":"2019-09-16T09:16:10","slug":"%e7%94%a2%e5%ad%b8%e5%90%88%e4%bd%9c%e6%88%90%e6%9e%9c%e5%88%86%e4%ba%ab%e5%be%ae%e7%94%9f%e7%89%a9%e7%94%a2%e7%94%9f%e4%b9%8b%e4%b8%81%e9%85%b8%e6%96%bc%e7%89%99%e6%a0%b9%e5%b0%96%e7%89%99%e5%91%a8","status":"publish","type":"post","link":"https:\/\/newsletter.cgust.edu.tw\/?p=2309","title":{"rendered":"[\u7522\u5b78\u5408\u4f5c\u6210\u679c\u5206\u4eab]\u5fae\u751f\u7269\u7522\u751f\u4e4b\u4e01\u9178\u65bc\u7259\u6839\u5c16\u7259\u5468\u767c\u708e\u904e\u7a0b\u4e4b\u89d2\u8272-\u57fa\u790e\u91ab\u5b78\u7d44 \u5f35\u7f8e\u59ec\u6559\u6388"},"content":{"rendered":"\n<p>\u7814\u767c\u8655 \u9673\u96c5\u745c   2019-08-27<\/p>\n\n\n\n<p class=\"has-medium-font-size\">\u77ed\u934a\u8102\u80aa\u9178\u5728\u7259\u5468\u75c5\u7684\u9032\u884c\u626e\u6f14\u91cd\u8981\u89d2\u8272\uff0c\u77ed\u934a\u8102\u80aa\u9178(\u4e19\u9178. \u4e01\u9178)\u7684\u6fc3\u5ea6\u5728\u7259\u9f66\u6e9d\u6db2\u4e2d\u53ef\u9054mM level\uff0c\u4e14\u7259\u5468\u75c5\u7d93\u904e\u6cbb\u7642\u5f8c\u7259\u9f66\u6e9d\u6db2\u4e2d\u4e19\u9178\u3001\u4e01\u9178\u7684\u6fc3\u5ea6\u6703\u964d\u4f4e\uff0c\u56b4\u91cd\u7259\u5468\u75c5\u60a3\u8005\u7259\u9f66\u6e9d\u6db2\u4e2d\u4e01\u9178\u7684\u6fc3\u5ea6\u88ab\u5831\u544a\u7d04\u70ba2.6 mM\uff0c\u8f15\u5fae\u7259\u5468\u75c5\u6642\u5247\u6fc3\u5ea6\u7d04\u70ba0.2 mM\u3002\u4f46\u4e5f\u6709\u5831\u544a\u767c\u73fe\u7259\u5468\u75c5\u60a3\u8005\u7259\u9f66\u6e9d\u6db2\u4e2d\u4e01\u9178\u7684\u6fc3\u5ea6\u53ef\u9054 0.5-16 mM. \u9664\u4e86P. gingivalis\u4e4b\u5916\uff0c\u8a31\u591a\u5176\u4ed6\u6839\u7ba1\u5fae\u751f\u7269\u5982<em>Fusobacterium, Actinobacteria phylum, Parvimonas\nmicra<\/em>\u7b49\u4e5f\u6703\u7522\u751f\u77ed\u7df4\u916f\u80aa\u9178\uff0c\u6839\u7ba1\u6cbb\u7642\u524d\u611f\u67d3\u7684\u6839\u7ba1\u4e2d\u6709\u8f03\u591a\u91cf\u7684\u4e01\u9178\u8207\u4e19\u9178\uff0c\u7d93\u904e\u6cbb\u7642\u5f8c\u5247\u91cf\u6703\u964d\u4f4e\u3002 \u4e01\u9178\u6703\u6291\u5236\u7259\u9f66\u8868\u76ae\u7d30\u80de\u8207\u7e96\u7dad\u6bcd\u7d30\u80de\u7684\u751f\u9577\uff0c\u4e5f\u6703\u8a98\u767c\u767d\u8840\u7403\u7d30\u80de\u7684\u6b7b\u4ea1\u8207cytokine\u7684\u7522\u751f. \u4e01\u9178\u4e5f\u6703\u6291\u5236\u8868\u76ae\u7d30\u80de\u8207\u7e96\u7dad\u6bcd\u7d30\u80de\u7684\u9644\u8457\u8207\u86cb\u767d\u8cea\u5408\u6210\u7b49. \u4e01\u9178\u6703\u6291\u5236Con-A\u6240\u523a\u6fc0\u7684\u813e\u81dfT\u7d30\u80de interleukin 2 (IL-2)\u3001 IL-4\u3001 IL-5\u3001 IL-6 and IL-10 \u7522\u751f\u7b49\u514d\u75ab\u53cd\u61c9. \u76f4\u63a5\u5c07\u4e01\u9178\u8655\u7406\u7259\u9f66\u7d44\u7e54\u8868\u9762\u6703\u8a98\u767c\u7d44\u7e54\u7684\u767c\u708e\u53cd\u61c9\u8207\u7d30\u80de\u4ecb\u767d\u8cea(cytokine)\u7684\u91cb\u653e. Ho &amp; Chang (2007)\u4e5f\u767c\u73fe\u4e01\u9178\u5c0d\u7259\u9ad3\u7d30\u80de\u5177\u6709\u7d30\u80de\u6bd2\u6027\uff0c\u4e14\u6bd2\u6027\u8207\u7d30\u80de\u4e2dglutathione\u7684\u4e0b\u964d\u6709\u95dc; \u9019\u986f\u793a\u4e01\u9178\u65bc\u7259\u5468\u75c5\u81f4\u75c5\u904e\u7a0b\u7684\u91cd\u8981\u6027\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size\">\u4e00\u822c\u4f86\u8aaa\uff0c\u77ed\u934a\u8102\u80aa\u9178\u5177\u6297\u767c\u708e\u4f5c\u7528\uff0c\u751a\u81f3\u6291\u5236\u5927\u8178\u764c\u7684\u767c\u751f\u8207\u9032\u884c, \u4f46\u4e5f\u6709\u5831\u544a\u986f\u793a\u77ed\u934a\u8102\u80aa\u9178\u8a98\u5c0e\u767c\u708e\u4f5c\u7528. \u77ed\u934a\u8102\u80aa\u9178\u8a98\u5c0e\u8178\u9053\u8868\u76ae\u7d30\u80de\u767c\u708e\u4ecb\u8cea\u91cb\u653e\u7684\u4f5c\u7528\u548cGPR41\u3001 GPR43\u5169\u7a2e\u53d7\u9ad4\u4e4b\u6d3b\u5316\u6709\u95dc, \u9032\u800c\u6d3b\u5316p38\u8207 ERK\uff0c\u53ef\u63d0\u4f9b\u5c40\u90e8\u7d44\u7e54\u7684\u4fdd\u8b77\u514d\u75ab\u80fd\u529b\u4ee5\u53ca\u7d44\u7e54\u767c\u708e. \u4e01\u9178\u6703\u523a\u6fc0ROS17\/2.8\u9aa8\u7d30\u80de\u682a\u7d30\u80dePGE2\u7684\u7522\u751f\u4ee5\u53ca\u74b0\u6c27\u9176(COX)\u4e4b\u8868\u73fe\uff0c\u8abf\u63a7EP1\u548cEP2\u53d7\u9ad4\u8868\u73fe. Niederman \u7b49\u4eba (1997)\u7684\u7814\u7a76\u4e5f\u652f\u6301\u77ed\u934a\u8102\u80aa\u9178\u6703\u523a\u6fc0\u767c\u708e\u4ecb\u8cea\u7684\u7522\u751f. \u4f46\u662f\u77ed\u934a\u8102\u80aa\u9178\u65bc\u7d44\u7e54\u767c\u708e\u626e\u6f14\u4e4b\u78ba\u5207\u89d2\u8272\u4e26\u4e0d\u5b8c\u5168\u6e05\u695a\u3002\u77ed\u934a\u8102\u80aa\u9178\u6703\u523a\u6fc0\u767c\u708e\u7269\u8cea\u7684\u7522\u751f, \u4e26\u5728cystic fibrosis\u60a3\u8005\u6c23\u9053\u767c\u708e\u75be\u75c5\u9032\u7a0b\u626e\u6f14\u76f8\u7576\u4e4b\u91cd\u8981\u6027. \u96d6\u7136\u5230\u76ee\u524d\u524d\u70ba\u6b62, GPR\u6d3b\u5316\u65bc\u7d44\u7e54\u767c\u708e\u7684\u89d2\u8272\u4e26\u4e0d\u4e00\u81f4, GPR41\u548cGPR43\u5df2\u88ab\u5831\u544a\u8207\u6162\u6027\u767c\u708e\u75be\u75c5\u5982\u5927\u8178\u708e(colitis)\uff0c\u6c23\u5598(asthma)\u4ee5\u53ca\u95dc\u7bc0\u708e(arthritis)\u7b49\u6709\u95dc\u4fc2 (Ang &amp; Ding, 2016). \u77ed\u934a\u8102\u80aa\u9178\u53ca\u5176\u53d7\u9ad4\u5728\u7259\u5468\u8207\u6839\u5c16\u767c\u708e\u7684\u91cd\u8981\u6027\u4ecd\u6709\u5f85\u91d0\u6e05\u3002 <\/p>\n\n\n\n<p><strong>\u53c3\u8003\u6587\u737b:<\/strong><\/p>\n\n\n\n<p>Ang Z, Ding JL (2016) Mol Pharmacol 89: 388-398.<br>Ho YC, Chang YC (2007) J Endod 33: 437-441<br>Iida T, Kawato T, Tanaka H, Tanabe N, Nakai K, Zhao N, Suzuki N, Ochiai K, <br>Kurita-Ochiai T, Seto S, Suzuki N et al (2008) J Dent Res 87: 51-5.<br>Maeno M (2011) Arch Oral Biol 56: 678-86.<br>Jeng JH, Chan CP, Ho YS, Lan WH, Hsieh CC, Chang MC. J Periodontol 1999;70:1435-1442.<br>Niederman R, Zhang J, Kashket S.. Crit Rev Oral Biol Med 1997;8:269-290.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7814\u767c\u8655 \u9673\u96c5\u745c 2019-08-27 \u77ed<\/p>\n","protected":false},"author":1,"featured_media":2317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","_eb_attr":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-2309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teaching"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>[\u7522\u5b78\u5408\u4f5c\u6210\u679c\u5206\u4eab]\u5fae\u751f\u7269\u7522\u751f\u4e4b\u4e01\u9178\u65bc\u7259\u6839\u5c16\u7259\u5468\u767c\u708e\u904e\u7a0b\u4e4b\u89d2\u8272-\u57fa\u790e\u91ab\u5b78\u7d44 \u5f35\u7f8e\u59ec\u6559\u6388 - 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