{"id":11019,"date":"2024-12-06T17:13:33","date_gmt":"2024-12-06T09:13:33","guid":{"rendered":"https:\/\/newsletter.cgust.edu.tw\/?p=11019"},"modified":"2024-12-09T11:18:27","modified_gmt":"2024-12-09T03:18:27","slug":"%e4%bb%a5%e4%ba%8c%e6%b0%a7%e5%8c%96%e7%a2%b3%e9%9b%b7%e5%b0%84%e4%bd%9c%e7%82%ba%e6%96%b0%e7%a9%8e%e5%b7%a5%e5%85%b7%e4%bf%83%e9%80%b24-n-%e4%b8%81%e5%9f%ba%e9%96%93%e8%8b%af%e4%ba%8c%e9%85%9a","status":"publish","type":"post","link":"https:\/\/newsletter.cgust.edu.tw\/?p=11019","title":{"rendered":"\u4ee5\u4e8c\u6c27\u5316\u78b3\u96f7\u5c04\u4f5c\u70ba\u65b0\u7a4e\u5de5\u5177\u4fc3\u90324-n-\u4e01\u57fa\u9593\u82ef\u4e8c\u915a\u4e4b\u7d93\u76ae\u5438\u6536"},"content":{"rendered":"\n<p class=\"has-black-color has-text-color has-link-color has-medium-font-size wp-elements-bef59275b458c249272d690d3aa60066\" style=\"font-style:normal;font-weight:400\">\u98df\u54c1\u66a8\u5316\u599d\u54c1\u5b89\u5168\u7814\u7a76\u4e2d\u5fc3\u53ca\u5316\u599d\u54c1\u61c9\u7528\u7cfb \u9ec3\u4fca\u85b0<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color has-medium-font-size wp-elements-a24e2fda19119c32c51ba4face22a689\" style=\"font-style:normal;font-weight:400\">\u7d93\u76ae\u5438\u6536\u662f\u4e00\u7a2e\u900f\u904e\u76ae\u819a\u50b3\u905e\u6cbb\u7642\u6027\u85e5\u7269\u7684\u65b9\u5f0f\u3002\u85e5\u7269\u5728\u7a7f\u900f\u76ae\u819a\u6642\u5fc5\u9808\u514b\u670d\u4e3b\u8981\u5c4f\u969c\u2013\u89d2\u8cea\u5c64\uff0c\u9019\u70ba\u85e5\u7269\u50b3\u905e\u5230\u9054\u76ee\u6a19\u4f4d\u7f6e\u69cb\u6210\u4e86\u6975\u5927\u7684\u6311\u6230\uff0c\u5c24\u5176\u662f\u5c0d\u65bc\u89aa\u6c34\u6027\u5206\u5b50\u8207\u5927\u5206\u5b50\u800c\u8a00\uff0c\u7a7f\u900f\u89d2\u8cea\u5c64\u7684\u96e3\u5ea6\u66f4\u9ad8\u3002\u70ba\u4e86\u514b\u670d\u9019\u4e00\u969c\u7919\uff0c\u904e\u53bb\u7684\u7814\u7a76\u5df2\u958b\u767c\u51fa\u591a\u7a2e\u6280\u8853\uff0c\u5305\u62ec\u4f7f\u7528\u81a0\u5e36\u53bb\u9664\u89d2\u8cea\u5c64(\u525d\u96e2\u6280\u8853)\u3001\u65bd\u52a0\u96fb\u5834\u4ee5\u4fc3\u9032\u5e36\u96fb\u5206\u5b50\u901a\u904e\u76ae\u819a(\u96e2\u5b50\u5c0e\u5165\u6cd5)\uff0c\u4ee5\u53ca\u5229\u7528\u96fb\u7a7f\u5b54\u6280\u8853(electroporation)\u5728\u76ae\u819a\u5c64\u4e2d\u5f62\u6210\u5fae\u5c0f\u901a\u9053(Bachhay et al., 2010)\u3002\u7136\u800c\uff0c\u90e8\u5206\u6280\u8853\u56e0\u96e3\u4ee5\u7cbe\u78ba\u63a7\u5236\u4e14\u7f3a\u4e4f\u53ef\u91cd\u8907\u6027\uff0c\u751a\u81f3\u53ef\u80fd\u5c0e\u81f4\u76ae\u819a\u523a\u6fc0\u548c\u75bc\u75db\u3002\u56e0\u6b64\uff0c\u5728\u61c9\u7528\u4e0a\u9020\u6210\u986f\u8457\u7684\u9650\u5236(Mikszta et al., 2002)\u3002<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color has-medium-font-size wp-elements-2c9db013131c627615c5fba4cd8ca536\" style=\"font-style:normal;font-weight:400\">4-n-\u4e01\u57fa\u9593\u82ef\u4e8c\u915a(4-n-Butylresorcinol)\u662f\u4e00\u7a2e\u5e38\u7528\u65bc\u6291\u5236\u9ed1\u8272\u7d20\u751f\u6210\u53ca\u7f8e\u767d\u7522\u54c1\u4e2d\u7684\u6d3b\u6027\u6210\u5206\uff0c\u5728\u81e8\u5e8a\u4e0a\u89c0\u5bdf\u5230\u5c0d\u76ae\u819a\u8272\u7d20\u6c89\u8457\u7684\u6539\u5584\u5177\u6709\u6975\u9ad8\u7684\u6f5b\u529b(Kolbe et al., 2013)\uff0c\u76ee\u524d\u95dc\u65bc\u5176\u7d93\u76ae\u5438\u6536\u7279\u6027\u7684\u7814\u7a76\u4ecd\u7136\u6709\u9650\u3002\u672c\u7814\u7a76\u5718\u968a\u5229\u7528\u4e8c\u6c27\u5316\u78b3\u96f7\u5c04\u53bb\u9664\u89d2\u8cea\u5c64\u969c\u7919(\u5982\u5716\u4e00\u3001\u5716\u4e8c\u6240\u793a)\uff0c\u8a55\u4f30\u5176\u5c0d4-n-\u4e01\u57fa\u9593\u82ef\u4e8c\u915a\u7d93\u76ae\u5438\u6536\u7684\u4fc3\u9032\u6548\u679c\u3002\u7814\u7a76\u8b49\u5be6\u4e8c\u6c27\u5316\u78b3\u96f7\u5c04\u80fd\u986f\u8457\u63d0\u53474-n-\u4e01\u57fa\u9593\u82ef\u4e8c\u915a\u7684\u7d93\u76ae\u5438\u6536\u80fd\u529b\uff0c\u70ba\u81e8\u5e8a\u61c9\u7528\u63d0\u4f9b\u4e86\u5bf6\u8cb4\u7684\u53c3\u8003\u6578\u64da(Hsiao et al., 2024)\u3002<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color has-medium-font-size wp-elements-c9d6b687db6f44072bca1c2efda10536\" style=\"font-style:normal;font-weight:400\">\u7d93\u76ae\u5438\u6536\u6548\u7387\u7684\u63d0\u5347\u8207\u89d2\u8cea\u5c64\u53bb\u9664\u7a0b\u5ea6\u5bc6\u5207\u76f8\u95dc\u3002\u7576\u89d2\u8cea\u5c64\u88ab\u6709\u6548\u6d88\u9664\u5f8c\uff0c\u8a66\u9a57\u85e5\u7269\u5f97\u4ee5\u7a7f\u900f\u76ae\u819a\u4e26\u5230\u9054\u76ee\u6a19\u4f4d\u7f6e\u767c\u63ee\u6cbb\u7642\u6210\u6548\u3002\u7531\u65bc\u96f7\u5c04\u8f14\u52a9\u7d93\u76ae\u85e5\u7269\u50b3\u905e\u6280\u8853\u4e0d\u65b7\u9032\u6b65\uff0c\u4e26\u5177\u6709\u5ee3\u6cdb\u7684\u81e8\u5e8a\u61c9\u7528\u6f5b\u529b\u3002\u591a\u9805\u7814\u7a76\u5df2\u8b49\u5be6\uff0c\u5c0d\u76ae\u819a\u9032\u884c\u96f7\u5c04\u9810\u8655\u7406\u53ef\u589e\u5f37\u85e5\u7269\u5728\u5c40\u90e8\u548c\u5168\u8eab\u61c9\u7528\u4e2d\u7684\u7a7f\u900f\u6df1\u5ea6\u548c\u6ef2\u900f\u6027(Sklar et al., 2014)\u3002\u5728\u81e8\u5e8a\u4e0a\uff0c\u96f7\u5c04\u88ab\u7528\u4f86\u589e\u5f37\u8089\u6bd2\u687f\u83cc\u6bd2\u7d20\u7684\u7d93\u76ae\u5438\u6536\uff0c\u5f9e\u800c\u6210\u70ba\u6cbb\u7642\u591a\u6c57\u75c7\u7684\u4e00\u7a2e\u6709\u6548\u4e14\u5b89\u5168\u7684\u8f14\u52a9\u5de5\u5177(Agamiaet et al., 2021)\u3002\u672a\u4f86\u5728\u9078\u64c7\u4fc3\u9032\u7d93\u76ae\u5438\u6536\u7684\u5de5\u5177\u6642\uff0c\u96f7\u5c04\u6280\u8853\u4ecd\u662f\u6709\u6f5b\u529b\u7684\u65b0\u7a4e\u5de5\u5177\u4e4b\u4e00\u3002<\/p>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"178\" height=\"114\" src=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2024\/12\/20241206.png\" alt=\"\" class=\"wp-image-11021\" style=\"width:557px;height:auto\"\/><figcaption class=\"wp-element-caption\">\u5716\u4e00\u3001\u7a7f\u900f\u5f0f\u96fb\u5b50\u986f\u5fae\u93e1\u89c0\u5bdf\u8c6c\u76ae\u672a\u7d93\u4e8c\u6c27\u5316\u78b3\u96f7\u5c04\u8655\u7406<\/figcaption><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"179\" height=\"116\" src=\"https:\/\/newsletter.cgust.edu.tw\/wp-content\/uploads\/2024\/12\/2024120601.png\" alt=\"\" class=\"wp-image-11022\" style=\"width:556px;height:auto\"\/><figcaption class=\"wp-element-caption\">\u5716\u4e8c\u3001\u7a7f\u900f\u5f0f\u96fb\u5b50\u986f\u5fae\u93e1\u89c0\u5bdf\u8c6c\u76ae\u7d93\u4e8c\u6c27\u5316\u78b3\u96f7\u5c04\u8655\u7406<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color has-medium-font-size wp-elements-b9ffdee53d24862049ea202550b28a2c\" style=\"font-style:normal;font-weight:400\">Agamia, N. C., Sobhy, N., Abd-Elraouf, A., &amp; Tawfik, A. (2021). Fractional CO<sub>2<\/sub> laser for transcutaneous drug delivery of onabotulinum toxin in palmar hyperhidrosis. <em>Clinical Trial Dermatol Surg, 47<\/em>(5), 678-683. doi: 10.1097\/DSS.0000000000002901<\/p>\n\n\n\n<p class=\"has-link-color has-medium-font-size wp-elements-261f5eb486ff89bfb903d9022d0bc05e\" style=\"font-style:normal;font-weight:400\">Bachhav, Y. G., Summer, S., Heinrich, A., Bragagna,T., B\u00f6hler, C., &amp; Kalia, Y. N. (2010). Effect of controlled laser microporation on drug transport kinetics into and across the skin. <em>Journal of Controlled Release, 146<\/em>(1), 31\u201336. <a href=\"https:\/\/doi.org\/10.1016\/j.jconrel.2010.05.025\">https:\/\/doi.org\/10.1016\/j.jconrel.2010.05.025<\/a><\/p>\n\n\n\n<p class=\"has-link-color has-medium-font-size wp-elements-bb87af8c9fbb7323e14275b2b39c8fef\" style=\"font-style:normal;font-weight:400\">Hsiao, C. Y &amp; Huang, C. H. (2024). Using CO<sub>2<\/sub> laser treatment to enhance skin permeation of 4-n-butylresorcinol.<em> Chang Gung Journal of Science, 40<\/em>, 75-81.<\/p>\n\n\n\n<p class=\"has-link-color has-medium-font-size wp-elements-1520ec5ddf7148d9f5ed8a4e087dd16d\" style=\"font-style:normal;font-weight:400\">Kolbe, L., Mann, T., &amp; Gerwat, W. (2013). 4-n-butylresorcinol, a highly effective tyrosinase inhibitor for thetopical treatment of hyperpigmentation. <em>Journal of The European Academy of Dermatology and Venereology, 27 <\/em>Suppl 1, 19-23. https:\/\/doi.org\/10.1111\/jdv.12051<\/p>\n\n\n\n<p class=\"has-black-color has-text-color has-link-color has-medium-font-size wp-elements-b7514da9ebafd03de0779e184a2c9244\" style=\"font-style:normal;font-weight:400\">Mikszta, J. A., Alarcon, J. B., Brittingham, J. M., Sutter, D. E., Pettis, R. J., &amp; Harvey, N. G. (2002). Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery. <em>Nature Medicine, 8<\/em>(4), 415-419. https:\/\/doi.org\/10.1038\/nm0402-415 Sklar, L. R., Burnett, C. T., Waibel, J. S., Moy, R. L., &amp; Ozog, D. M. (2014). Laser assisted drug delivery: a review of an evolving technology. <em>Lasers in Surgery and Medicine, 46<\/em>(4), 249-262. https:\/\/doi.org\/10.1002\/lsm.22227<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u98df\u54c1\u66a8\u5316\u599d\u54c1\u5b89\u5168\u7814\u7a76\u4e2d\u5fc3\u53ca\u5316\u599d\u54c1\u61c9\u7528\u7cfb <\/p>\n","protected":false},"author":1,"featured_media":11022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"colormag_page_container_layout":"default_layout","colormag_page_sidebar_layout":"default_layout","_eb_attr":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-11019","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teaching"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - 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